was the treatment of choice for migraine in the last
[i] , and modern reports [ii] have echoed the traditional
view. Anecdotal evidence of using cannabis
for alleviation of migraine symptoms is provided by
Ogborne et al [iii] , Williamson &
Evans [iv] , and Schnelle et al [v] , who found 6.6% of surveyed medicinal users reported
using cannabis to relieve migraine.
et al [vi] found cannabinoids blocked serotonin release
from platelets in migraine patients. Russo
[vii] , reviewing the historical evidence,
or Marijuana, has been used for centuries for both
symptomatic and prophylactic treatment of migraine.
It was highly esteemed as a headache remedy by the
most prominent physicians of the age between 1874
and 1942, remaining part of the Western pharmacopoeia
for this indication even into the mid-twentieth century.
Current ethnobotanical and anecdotal references continue
to refer to its efficacy for this malady, while biochemical
studies of THC and anandamide have provided a scientific
basis for such treatment. The author believes that
controlled clinical trials of Cannabis in acute migraine
treatment are warranted.'
Heinemann [viii] reported incidence of headaches among users
of hashish. El-Mallakh et al
[ix] reported "Onset
of migraines occurred prior to onset of substance
use, while onset of tension headaches occurred after
onset of substance use'and suggested
"migraines may play
a role in the genesis of substance use'
Other than pain relief in general, there is as yet
insufficient scientific evidence to indicate whether
or not cannabinoids may specifically relieve, or indeed
exacerbate, symptoms among migraine sufferers.
Lowered blood pressure is a common systemic effect
of cannabis use which could potentially reduce the
risk and/or severity of migraines. There are
widespread anecdotal reports of benefits, and cannabis
products did play a role in treatment of migraine
in the early years of modern medicine.